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KMID : 1098420040120040309
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Korean Journal of Medicinal Crop Science
2004 Volume.12 No. 4 p.309 ~ p.314
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Cytotoxicity of Extracts and Fractions from Echinacea pupurea L. on Human Cancer Cells
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Park JIn-Hong
Lee Mi-Kyoung
Mun Hyoung-Chul
Choi Geun-Pyo
Lee Seo-Ho
Lee Hyun-Soo
Ryu Lee-Ha
Lee Kang-Yoon
Lee Hyeon-Yong
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Abstract
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The cytotoxic effects of water and ethanol extracts of Echinacea purpurea (L.) (EP) and chloroform, ethyl acetate, butanol and aqueous fractions from each extract of EP were examined. Every extract and fraction of EP inhibited the growth of human hepatocarcinoma, human gastric cancer cell, human breast cancer cells and human lung carcunoma in concentration-dependent manners over a concentration range of 0.05{sim}1.0;mg/ml. Most extracts and fractions with the concentraction of 1 mg/ml showed strong inhibition of more than 70% for every cancer cell. Only aqueous fractions of each extract showed very weak inhibitons of 12 to 25% on the growth of human normal lung cell with the concentration of 1 mg/ml. Overall selectivity of the extrats and fractions on the four human cancer cell lines was over 2.5. These results indicate that EP has a very potent selective toxicity for cancer cells.
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KEYWORD
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Echinacea purpurea L, extracts, fractions, cytotoxic activities, human lung carcunoma
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